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Despicable Me 4 is a 2024 American animated comedy film produced by Universal Pictures and Illumination, and distributed by Universal. It serves as the sequel to Despicable Me 3 (2017), the fourth main installment, and the sixth overall installment in the Despicable Me franchise. The film was directed by Chris Renaud, co-directed by Patrick Delage (in his feature directorial debut), produced by Chris Meledandri and Brett Hoffman, and written by Mike White and Ken Daurio. It stars the voices of Steve Carell, Kristen Wiig, Pierre Coffin, Joey King, Miranda Cosgrove, Steve Coogan, Sofía Vergara, Renaud, Madison Polan, Dana Gaier, Chloe Fineman, Stephen Colbert, and Will Ferrell. In the film, Gru and his family are forced to relocate to a safe house to hide from Maxime Le Mal, an old rival of Gru who seeks revenge with his girlfriend Valentina. At the same time, one of the new neighbors is intent on returning Gru to villainy.

Development on a fourth Despicable Me film began in September 2017. It was officially confirmed in February 2022, with Renaud, Delage, and White attached as director, co-director, and writer, respectively. Production was underway by June 2022. Most of the main voice cast was announced in January 2024, with Hoffman and Daurio revealed as co-producer and co-writer, respectively. Heitor Pereira and Pharrell Williams returned from previous installments to compose the score and write original songs and themes, respectively.

Despicable Me 4 premiered at the Jazz at Lincoln Center in New York City on June 9, 2024. It was theatrically released in Australia on June 20 and in the United States on July 3. The film received mixed reviews from critics and has grossed $100.7 million worldwide.