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Teenage Mutant Ninja Turtles: Mutant Mayhem is a 2023 American computer-animated superhero film directed by Jeff Rowe (in his feature directorial debut), co-directed by Kyler Spears, and written by Rowe, Seth Rogen, Evan Goldberg, Dan Hernandez, and Benji Samit. It is the seventh theatrical Teenage Mutant Ninja Turtles film and stars the voices of Micah Abbey, Shamon Brown Jr., Nicolas Cantu, and Brady Noon as the titular team. The supporting ensemble voice cast includes Hannibal Buress, Rose Byrne, John Cena, Jackie Chan, Ice Cube, Natasia Demetriou, Ayo Edebiri, Giancarlo Esposito, Post Malone, Rogen, Paul Rudd, and Maya Rudolph. In the film, after years of being sheltered from the human world, the Turtles set out to be accepted as normal teenagers through acts of heroism. The brothers go on a hunt for a mysterious crime syndicate, but trouble arises when an army of mutants is unleashed upon them.

Nickelodeon announced Mutant Mayhem in June 2020, with Rogen, Goldberg, and James Weaver producing under their Point Grey Pictures banner, and Rowe as director. Spears joined as co-director soon after. The animation was provided by Mikros Animation in Montreal and Paris and Cinesite in Vancouver and was primarily influenced by school notebook sketches. Seeking to explore the teenage aspect of the Turtles, the filmmakers drew inspiration from teenage coming-of-age films. The majority of the cast was announced in March 2023, with the Turtles voiced by teenage actors (Abbey, Brown, Cantu, and Noon) for the first time. Trent Reznor and Atticus Ross composed the musical score.

Mutant Mayhem was screened as a work-in-progress at the Annecy International Animation Film Festival on June 12, 2023, and is scheduled to be released in the United States on August 2, by Paramount Pictures.