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Ghostbusters: Afterlife (titled Ghostbusters: Legacy or Ghostbusters: From Beyond in some markets) is an upcoming American supernatural comedy-drama film directed by Jason Reitman and written by Reitman and Gil Kenan. It stars Carrie Coon, Finn Wolfhard, Mckenna Grace, and Paul Rudd, while Bill Murray, Dan Aykroyd, Ernie Hudson, Sigourney Weaver, and Annie Potts reprise their roles from the original films. It is the direct sequel to Ghostbusters (1984) and Ghostbusters II (1989) and the fourth film overall in the Ghostbusters franchise. Set thirty years after the second film, a family moves to a small town, where they discover their connection to the original Ghostbusters and their grandfather's secret legacy.

A third Ghostbusters film had been in various stages of development since Ghostbusters II in 1989. After Murray refused to commit to the project and after the death of cast member Harold Ramis in 2014, Sony instead produced a reboot. After the film underperformed at the box office, Reitman began developing a sequel to the original films. The new cast members were announced by July 2019, while the original cast signed on two months later.

Ghostbusters: Afterlife is scheduled to be released in the United States on November 11, 2021, after being delayed three times from an original July 2020 date due to the COVID-19 pandemic. The film will be released in IMAX, RealD 3D and Dolby Cinema.