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Metroid II: Return of Samus is an action-adventure game developed and published by Nintendo for the Game Boy. The first Metroid game for a handheld game console, it was released in North America in November 1991 and in Japan and Europe in 1992. The game follows bounty hunter Samus Aran on her mission to exterminate the Metroids from their home planet before the Space Pirates can obtain them. Players must find and destroy the Metroids to progress through the planet's tunnels.

The developer of the original Metroid for the Nintendo Entertainment System – Nintendo Research & Development 1 (Nintendo R&D1) – and producer Gunpei Yokoi returned to develop Metroid II. Samus's round-shouldered Varia Suit, created to differentiate it from her standard suit on the Game Boy's black-and-white palette, became a staple of the series.

Metroid II received mainly positive reviews. Critics praised its story and settings, but criticized its graphics and audio. By late 2003, the game had sold 1.72 million copies worldwide. A sequel, Super Metroid, was released for the Super Nintendo Entertainment System in 1994. Metroid II was re-released as part of the Nintendo 3DS's Virtual Console service in 2011. After halting development of a fan remake, AM2R, Nintendo released an official remake, Metroid: Samus Returns, on the Nintendo 3DS in 2017.